Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

[Silane coupling agents].

Biosensors Using Micromachined Polyimide Probes

This paper explores the electrochemical patterning of thin metal films using a scanning probe tip as an electrode. In particular, a masking nickel film is etched to reveal a gold pattern to which biomolecules like liposomes and proteins can be attached after treatment with functionalized self assembled monolayers (SAMs) of gold-thiolate. The machining is performed by ultracomplaint polyimide mi...

Synthesis and antimicrobial activity of quaternary ammonium silane coupling agents.

Fourteen novel silane coupling agents with a quaternary ammonium group introduced into the molecule, [CH(2)=CHCH(2)N(+)(CH(3))(C(n)H(2n+1))(CH(2))(3)Si(OCH(3))(3)]X(-) (n-X, n=10-18, X=Cl, Br, or I), were synthesized with the aim of using these agents to make material surfaces antimicrobial for a long period of time. Measurements of the minimum inhibitory concentrations (MIC) against 12 kinds o...

Surface Reactions on Thin Layers of Silane Coupling Agents

The reactivity of immobilized functional groups in thin layers of (3-aminopropy1)triethoxy~ilane (APS), (3-mercaptopropyl)trimethoxy~ilane, (3-bromopropyl)trimethoxysilane, and (8-bromoody1)trimethoxysilane on oxidized aluminum substrates was studied with reflection-adsorption infrared spectroscopy (RAIR), optical ellipsometry and contact-angle measurements. Mass changes on the surface associat...

Attaching Biological Molecules to AFM Probes for Nanoscale Molecular Recognition Studies

Atomic Force Microscopy (AFM) is an important tool to study nanoscale molecular interactions. A strong suit of AFM is its ability to measure ligand-receptor interactions with picoNewton sensitivity. These biomolecular interactions are critical factors in a variety of physiological processes; such as the initiation, modulation and termination of DNA replication, transcription, enzyme activity, i...